How does c-Myc work?

How does c-Myc work?

c-Myc is a multifunctional transcription factor which drives the multiple synthetic functions necessary for rapid cell division while at the same time inhibiting expression of genes with antiproliferative functions. Because of its propensity to induce apoptosis, its expression is tightly regulated.

What does c-Myc regulate?

C-Myc protein is a member of a family of proteins that regulate cell proliferation and apoptosis. The ability of c-myc to regulate apoptotic cell death results from the coordinated activation of c-Myc and several protein partners (such as Max) that facilitate DNA binding and activate transcription.

How does Myc cause apoptosis?

c-MYC represses some of the survival pathways associated with death receptor and DISC activation, and this can promote apoptosis. Death receptor signaling can activate the nuclear factor-κB (NF-κB) transcription factor, which suppresses receptor-induced apoptosis.

Is c-Myc an oncogene or tumor suppressor?

Although the Myc gene was originally identified as an oncogene, it is involved in various cellular processes, including cell growth, proliferation, loss of differentiation, and apoptosis (Adhikary and Eilers, 2005; Pelengaris et al., 2002; Thompson, 1998).

What is the difference between Myc and c-myc?

In cancer, c-myc is often constitutively (persistently) expressed. This leads to the increased expression of many genes, some of which are involved in cell proliferation, contributing to the formation of cancer….Myc.

MYC proto-oncogene, bHLH transcription factor
Identifiers
Alt. symbols c-Myc, v-myc
NCBI gene 4609
HGNC 7553

What is the difference between N Myc and c-myc?

c-Myc is broadly overexpressed in both blood-borne and solid tumors. N-myc is most frequently overexpressed in solid cancers of neural origin, such as neuroblastoma and glioma.

What is the difference between N myc and c-myc?

What does C FOS stand for?

c-Fos

FOS
Aliases FOS, AP-1, C-p55, Fos proto-oncogene, AP-1 transcription factor subunit
External IDs OMIM: 164810 MGI: 95574 HomoloGene: 3844 GeneCards: FOS
showGene location (Human)
showGene location (Mouse)

What result does C-MYC have on transcription?

In cancer, c-myc is often constitutively (persistently) expressed. This leads to the increased expression of many genes, some of which are involved in cell proliferation, contributing to the formation of cancer….Myc.

MYC proto-oncogene, bHLH transcription factor
Identifiers
NCBI gene 4609
HGNC 7553
OMIM 190080

Is MYC a proto-oncogene?

The proto-oncogene, MYC, lies at the crossroads of many growth promoting signal transduction pathways and is an immediate early response gene downstream of many ligand-membrane receptor complexes (Armelin et al., 1984; Kelly et al., 1983) (Figure 1A).

Why myc is a proto-oncogene?

The proto-oncogene Myc is a transcription factor that promotes cell growth and proliferation, and regulates cell metabolism. Its overexpression also causes chromosomal instability. Overexpression of myc directed by the albumin promoter leads to development of HCC in more than 80% of male mice at 16 months.

When was c-myc discovered?

Identification of MYC In the late 1970s, an avian acute leukemia virus (MC29) was shown to promote a spectrum of malignancies, including myelocytomas, sarcomas, and importantly, carcinomas. This ability to induce carcinomas was of particular interest because this represented the most common form of human malignancy.

What are the different conditional knockout mouse protocols?

Today, protocols such as the Cre-lox recombination system are commonplace, and researchers are also coming up with newer, more complex conditional knockout protocols like the Red-pathway-mediated recombination. Before covering conditional knockout mouse protocol methods, it’s necessary to highlight the crucial role played by knockout mice.

What are some examples of conditional knockouts?

For example, conditional knockouts can be developed to impair a particular function that only affects the liver or to alter genes that affect the proper functioning of the heart.

What is the pathophysiology of a null c-Myc?

A null c-myc mutation causes lethality before 10.5 days of gestation in homozygotes and reduced fertility in heterozygous female mice. Genes Dev 1993;7:671-82 [ PubMed] [ Google Scholar]

Do different lineages of hematopoietic cells require c-Myc to regulate proliferation and differentiation?

Other models with conditional Myc deletion have demonstrated that different lineages of hematopoietic cells differ in their requirement for c-Myc to regulate their proliferation and differentiation. When transgenic mice overexpress c-Myc or N-Myc in mature cells from the lymphoid or myeloid lineages, the result is lymphoma or leukemia.