What does a positive Anticardiolipin IgM mean?

What does a positive Anticardiolipin IgM mean?

A positive result means that cardiolipin antibody was detected in the blood. As mentioned earlier, the presence of cardiolipin antibodies may indicate several diseases, such as: Syphilis. Antiphospholipid syndrome (APS) Systemic lupus erythematosus (SLE)

What does high cardiolipin IgG mean?

The levels of these antibodies are often high in people with abnormal blood clotting, autoimmune diseases like systemic lupus erythematosus (SLE), or repeated miscarriages.

What is a beta 2 glycoprotein test for?

The persistent presence of IgG and/or IgM beta 2 glycoprotein I (B2GPI) antibodies is a laboratory criterion for the diagnosis of antiphospholipid syndrome (APS).

What does a Anticardiolipin blood test test for?

The Anticardiolipin Antibodies test detects the cardiolipin antibodies IgA/ IgG/ IgM existence which is an essential process in the body’s ability to regulate blood clotting.

Is High IgM serious?

Hyper IgM syndromes are caused by very rare, one-in-a-million, and potentially life-threatening genetic mutations that severely compromise the immune system and resulting in the individual’s inability to produce antibodies. Patients with hyper IgM are at significant risk for opportunistic and repeated infections.

Can an anticardiolipin go from positive to negative?

An individual can be positive for anticardiolipin antibodies and negative for anti-ß2 GPI and vice versa, and detection of anti-ß2 GPI is not yet part of routine testing done for patients with an increased likelihood of blood clots.

What is normal range for cardiolipin?

Negative : <10.0 MPL U/ml. Weak Positive : 10.0-40.0 MPL U/ml. Positive: >40 MPL U/ml.

What is a normal cardiolipin level?

Weak positive: 15-40U/ml. Positive: >40 U/ml.

What is beta-2 glycoprotein normal range?

Normal: β2 GPI IgG ≤ 20 SGU U/mL. β2 GPI IgM ≤ 20 SMU U/mL.

What does a low beta-2 glycoprotein mean?

If the test is weakly to moderately positive for beta-2 glycoprotein 1 antibodies and weakly positive or negative for other antiphospholipid antibodies, it means the antibody may be due to a condition other than APS. If repeat testing is negative, then it is likely that the antibodies were temporary.

How serious is antiphospholipid syndrome?

Antiphospholipid (AN-te-fos-fo-LIP-id) syndrome occurs when your immune system mistakenly creates antibodies that make your blood much more likely to clot. This can cause dangerous blood clots in the legs, kidneys, lungs and brain.

How is anticardiolipin antibodies treated?

Your treatment plan Most people with APS need to take anticoagulant or antiplatelet medication daily for the rest of their life. If blood tests show you have abnormal antiphospholipid antibodies, but you don’t have a history of blood clots, low-dose aspirin tablets are usually recommended.