What is a silylation reaction?

What is a silylation reaction?

Silylation is the introduction of one or more (usually) substituted silyl groups (R3Si) to a molecule. The process is the basis of organosilicon chemistry.

What is Otms in organic chemistry?

A trimethylsilyl group (abbreviated TMS) is a functional group in organic chemistry. This group consists of three methyl groups bonded to a silicon atom [−Si(CH3)3], which is in turn bonded to the rest of a molecule.

What is protection and deprotection?

A protecting group or protective group is introduced into a molecule by chemical modification of a functional group to obtain chemoselectivity in a subsequent chemical reaction. It plays an important role in multistep organic synthesis. This step is called deprotection.

Why derivatization is done in GC Analyses?

The derivatization is typically done to change the analyte properties for a better separation and also for enhancing the method sensitivity. In GC/MS, derivatization may improve the capability of compound identification. Examples illustrating such improvements are included.

What is Desilylation and silylation?

Desilylation is the reverse of silylation: the silyl group is exchanged for a proton. Various fluoride salts (e.g. sodium, potassium, tetra-n-butylammonium fluorides) are popular for this purpose. CpFe (CO) 2 Si (CH 3) 3, a trimethylsilyl complex.

Is silylation a KIE reaction?

In principle, the silylation reaction is rapid and quantitative, and this is not accompanied by KIEs (Rieley et al., 1994). Prevalent methods for derivatization of amino acids and monosaccharides use t-BDMS or trimethylsilyl (TMS) derivatives.

What is the name of the reagent used for silylation?

Bis(trimethylsilyl)acetamide, a popular reagent for silylation. The introduction of a silyl group(s) gives derivatives of enhanced volatility, making the derivatives suitable for analysis by gas chromatography and electron-impact mass spectrometry (EI-MS).

Does iodine accelerate silylation of alcohols with silyl chlorides?

Reactions of alcohols with silyl chlorides in the presence of N -methylimidazole were significantly accelerated by addition of iodine. A general and high yielding method for efficient silylation of primary, secondary, and tertiary alcohols was developed. A. Bartoszewicz, M. Kalek, J. Nilsson, R. Hiresova, J. Stawinski, Synlett, 2008 , 37-40.