What did ALLHAT trial show?

What did ALLHAT trial show?

The ALLHAT blood pressure trial found that the calcium channel blocker, ACE inhibitor, and alpha-adrenergic blocker did not work better than the diuretic to control high blood pressure and prevent stroke and some forms of heart disease, including heart attack and heart failure.

When was the ALLHAT trial?

Design The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT), a randomized, double-blind, active-controlled clinical trial conducted from February 1994 through March 2002.

When was Allhat published?

Published in 2002, the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) sought to determine which of four agents antihypertensive performed best in terms of fatal CAD and nonfatal MI.

Is chlorthalidone better than lisinopril?

Chlorthalidone was associated with a small but significantly lower systolic pressure over the course of the study than amlodipine or lisinopril (133.9 versus 134.7 and 135.9 mmHg, respectively) and a higher proportion of patients who attained the blood pressure goal of less than 140/90 mmHg (68.2 versus 66.3 and 61.2 …

What is the side effects of chlorthalidone?

Chlorthalidone side effects

• nausea.
• vomiting.
• stomach cramping.
• diarrhea.
• constipation.
• loss of appetite.
• dizziness.
• headache.

Is chlorthalidone more effective than hydrochlorothiazide?

There are significant pharmacokinetic and pharmacodynamic differences between these diuretics. Chlorthalidone is ≈1.5 to 2.0 times as potent as hydrochlorothiazide, and the former has a much longer duration of action.

Which is better amlodipine or chlorthalidone?

Conclusions. Chlorthalidone is an antihypertensive drug equally effective as amlodipine after kidney transplantation.

Is chlorthalidone bad for your kidneys?

For people with kidney disease: Chlorthalidone can make your kidney problems worse. Talk with your doctor about whether taking this drug is safe for you. For people with liver disease: Chlorthalidone can cause changes in your fluid and electrolyte levels. This may even lead to coma.

Is chlorthalidone safe for kidneys?

Chlorthalidone increased the risk of the following side effects when compared to hydrochlorothiazide: Low potassium levels (hypokalemia), nearly three times greater risk. Low sodium levels (hyponatremia), 31 percent greater risk. Acute kidney failure, 37 percent greater risk.

Is chlorthalidone hard on the kidneys?

When is the best time to take chlorthalidone?

Chlorthalidone comes as a tablet to take by mouth. It usually is taken once a day or every other day after a meal, preferably breakfast. It is best to take this medicine in the morning to avoid going to the bathroom during the night.

Can I take amlodipine and chlorthalidone together?

Therefore, the combination of S-amlodipine and chlorthalidone is a good option for controlling the BP in patients unresponsive to CCB monotherapy.

What is the ALLHAT trial?

ALLHAT, supported by the National Heart, Lung, and Blood Institute (NHLBI), began in 1994 and lasted eight years. ALLHAT was the largest trial of treatments for high blood pressure and the second-largest trial of treatments for high cholesterol.

What does ALLHAT stand for?

– Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) The ALLHAT blood pressure trial involved more than 42,000 participants ages 55 and older. Participants had high blood pressure and at least one other risk factor for heart disease, such as cigarette smoking or type 2 diabetes.

What isallhat?

ALLHAT was the largest trial of treatments for high blood pressure and the second-largest trial of treatments for high cholesterol.

What is the ALLHAT blood pressure trial?

The ALLHAT blood pressure trial. The ALLHAT blood pressure trial involved more than 42,000 participants ages 55 and older. Participants had high blood pressure and at least one other risk factor for heart disease, such as cigarette smoking or type 2 diabetes.