What does ezetimibe simvastatin do?

What does ezetimibe simvastatin do?

Ezetimibe and simvastatin combination is used together with a proper diet to treat high cholesterol and triglyceride (fats) levels in the blood. This medicine may help prevent medical problems (eg, heart attack, stroke) caused by clogged blood vessels.

What is ezetimibe 10 mg tablet used for?

Ezetimibe is a type of medicine used to lower cholesterol. It’s used to treat high blood cholesterol. This is when you have too much of a fatty substance called cholesterol in your blood.

Is ezetimibe 10 mg a statin?

Ezetimibe is not a statin medication, it is a cholesterol absorption inhibitor. Ezetimibe,fenofibrate and statins are cholesterol lowering medications. Ezetimibe can be taken together with statins or fenofibrate as their cholesterol lowering effects are complementary.

Is ezetimibe a pcsk9 inhibitor?

If patients cannot achieve LDL cholesterol targets after maximum tolerable dose statins plus ezetimibe, a PCSK-9 inhibitor can be considered.

Which is better simvastatin or ezetimibe?

Simvastatin treatment increased the number of functionally active endothelial progenitor cells, whereas ezetimibe had no effect. Conclusions— Four weeks of simvastatin treatment improves endothelial function independently of LDL cholesterol lowering, at least in part by reducing oxidant stress.

Does ezetimibe cause liver damage?

Although very rare, ezetimibe-associated liver injury is a potentially serious complication. With hepatic inflammation due to ezetimibe, discontinue treatment and consider systemic steroids and anti-inflammatory agents, with weekly monitoring of liver function tests (ALT, AST, ALP, total bilirubin).

Does ezetimibe have side effects?

Some of the more common side effects that can occur with use of ezetimibe include: diarrhea. stuffy nose. viral infection of your nose, throat, and airways.

Can ezetimibe cause liver damage?

Is ezetimibe a good drug?

Ezetimibe is a safe and efficacious non-statin LDL-C-lowering agent particularly in high-risk patients, such as those post-ACS.

What is the mechanism of action of ezetimibe?

What Is the Mechanism of Action of Ezetimibe? Ezetimibe is a potent and selective inhibitor of cholesterol absorption that has been shown to reduce the overall delivery of cholesterol to the liver, thereby promoting the synthesis of LDL receptors, with a subsequent reduction of serum LDL-C.

What are the side effects of Zetia?

Side effects of Zetia include:

  • diarrhea,
  • back pain,
  • stomach or abdominal pain,
  • numbness or tingly feeling,
  • tired feeling,
  • headache,
  • dizziness,
  • depressed mood,

What is ezetimibe (Zetia)?

Ezetimibe (Zetia) – Class, Uses, Dose, Side effects, MOA, Brands 25 Ezetimibe (Zetia) is a novel class of lipid-lowering drugs that inhibits the absorption of cholesterol from the intestine. It acts on the brush border of the intestine limiting the stores of cholesterol in the liver.

How is ezetimibe used to lower cholesterol?

It may be used alone or in combination with an HMG-CoA reductase inhibitor (statin). Ezetimibe is in a class of medications called cholesterol-lowering medications. It works by preventing the absorption of cholesterol in the intestine.

What are the side effects of ezetimibe?

Cases of muscle problems ( myalgia and rhabdomyolysis) have been reported and are included as warnings on the label for ezetimibe. The incidence of overdose with ezetimibe is rare; subsequently, few data exist on the effects of overdose.

What are the treatment guidelines for ezetimibe?

Several treatment guidelines recommend adding ezetimibe in select high risk persons in whom LDL goals cannot be achieved by maximally tolerated statin alone. Ezetimibe is indicated in the United States as an add-on to dietary measures to reduce levels of certain lipids in people with: